Researchers say they’ve found an easy way to spur stem cells to build bone in mice… A discovery that could lead to new treatments for bone disease.
Researchers at the University of California San Diego have come across an efficient method to get human pluripotent stem cells.
The Researchers have done this by feeding them Adenosine, a naturally occurring molecule in the body. The stem-cell-derived bone tissue helped repair cranial bone defects in mice without developing tumors or causing infection.
The work could lead to regenerative treatments for patients with critical bone defects and soldiers who have suffered traumatic bone injuries.
Shyni Varghese, a bioengineering professor at UCSD & senior author of the study & her team showed they could control the differentiation of human pluripotent stem cells into functional osteoblasts – bone building cells – simply by adding the molecule Adenosine to their growth medium.
Stem-cell-derived tissues can also develop a type of tumor called teratomas — when cells differentiate the wrong way.The research team found that adding adenosine to the stem cell process helped build bone tissue in mice without any teratoma formation.
Varghese’s team is currently investigating exactly how adenosine signaling promotes bone formation. So far, they’ve attributed the signaling to a receptor on the stem cells’ surface, called the A2bR receptor, which binds to adenosine. But this mechanism still requires further study.
This work was supported by the National Institute of Health.
Source : Scitech daily
Edited by : Juilee Mhatre