Rutgers, Stanford Scientists successfully ‘transplant’ nerve cells into brain ON 3D scaffolds, possibly leading to brain therapies for Neurodegenerative diseases like Parkinson’s, ALS.
Scientists at Rutgers and Stanford Universities have developed a new technology which may help patients with neurodegenerative diseases like Parkinson’s.
Prabhas V. Moghe, a professor in the Dept. of Biomedical Engineering and Chemical and Biochemical Engineering at Rutgers University says, “The technology involves converting adult tissue derived stem cells into human neurons on 3D ‘scaffolds’ or tiny islands of fibres.
Moghe said a 3-D scaffold, developed by the scientists, consists of tiny polymer fibres. Hundreds of neurons attach to the fibres and branch out, sending their signals. Scaffolds are about 100 micrometers wide – roughly the width of a human hair. Scaffold technology results in a hundred fold increases in cell survival rates compared to other methods. That may eventually help people with Parkinson’s disease, multiple sclerosis amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, Alzheimer’s disease, spinal cord and traumatic brain injuries, and concussions.
“If you can transplant cells in a way that mimics how these cells are already configured in the brain, then you are one step closer to getting a brain to communicate with the cells that now you are transplanting.”
The paper was published in Nature Communications on 17th March, 2016, submitted on 28th June 2015 titled ‘Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds’.
Here’s the link to the original paper as published in Nature Communications:
Here’s an article about this paper on paper on Eureka Alert:
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Referencing and Drafting: Aditya Karmarkar